CD274 and neoplasm: While the use of nonspecific HDACi, such as panobinostat, are known to increase the expression of the immunosuppressive proteins program death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) on the cell surface of tumor cells10, selective HDAC6i have shown the opposite effect by either blunting or decreasing the expression of PD-L1.