Recently, it has also been shown by Thioflavin S-staining that TDP-43 forms amyloid-positive aggregates in ALS patients70, and the cytoplasmic inclusions in most cases of ALS/FTLD were found to be Thioflavin S-positive upon modifying the staining protocol to remove lipid autofluorescence background71. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.