Additionally, we studied the potential associations with blood factors associated with PN development, including vitamin B12, fasting glucose, TSH, and various immunoglobulins linked to neuropathies in dysproteinemias; specifically IgM, IgG, and IgA17, and with neuropathic pain as measured by the DN4 questionnaire25. The gene discussed is CD40LG; the disease is poikiloderma with neutropenia.