MAPT and Alzheimer disease: However, the BIN1-mediated increase in the intraneuronal pool of Aβ1–42 only weakly translated into higher extraneuronal levels of Aβ1–42, i.e., a core feature of AD, and several histochemical brain autopsy and cell culture studies suggested that alterations in BIN1 expression were associated with stronger tau pathology rather than Aβ15,16.