Recent genome-wide association studies (GWAS) have identified several loci that are associated with increased risk of AD, among which the single nucleotide polymorphisms (SNPs) in the bridging integrator 1 (BIN1) gene show the second highest odds-ratios for sporadic AD, superseded only by apolipoprotein E (APOE) variants3–7. Here, APOE is linked to Alzheimer disease.