In mild cognitive impairment (MCI) and AD dementia, the BIN1 rs744373 SNP was reported to be associated with higher cerebrospinal fluid (CSF) levels of total and phospho-tau but not with Aβ23, whereas others could not detect an association between the BIN1 rs744373 SNP and CSF tau or phospho-tau levels24. This evidence concerns the gene MAPT and Cognitive impairment.