In line with the results for global AV45 amyloid-PET uptake, we found no significant effect of the BIN1 rs744373 SNP on AV45 amyloid-PET uptake within the different amyloid stage ROIs (all p > 0.05, ANCOVAs, see Fig. 2b & Table 3 for statistics), when controlling for age, gender, education, ApoE ε4 status, diagnosis, and GM volume of the, respective, amyloid-stage ROIs. This evidence concerns the gene BIN1 and amyloidosis.