CXCL12 and neoplasm: In addition, CXCL9, CXCL10, and stromal-derived factor-1 (SDF-1) that are secreted by CAFs inhibit the recruitment of T cells, attract inhibitory T cells, and lead to the uncontrolled activity of effector T cells, which interferes with the interactions between T and tumor cells, and finally prevents the destruction of tumor [6].