The removal of FAP+ fibroblasts does not alter the number or type of tumor-infiltrating T cells but can activate the cells and the secretion of inflammatory factors, such as interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), which leads to anoxic necrosis of cancer and stromal cells promoting the immune-mediated control of tumor growth. The gene discussed is TNF; the disease is cancer.