In agreement, we found anti-TIF1 to be strongly associated with malignancy, however at a lower OR in terms of both cancer ever (OR 4.21) and CAM (OR 4.67) that was comparable to an adult American myositis cohort (OR 4.2 for CAM), indicating that patient demographics may have an influence on malignancy risk [32]. This evidence concerns the gene TRIM24 and cancer.