For CAR-T cells, most of the patients (86–91.4%) receiving anti-CD19 genetically-modified, autologous T cells tisagenlecleucel (indicated for relapsed/refractory B-cell ALL and diffuse large B-cell lymphoma [DLBCL]), were positive for anti-murine CAR19 antibodies prior to infusion [58, 59]. This evidence concerns the gene CD19 and diffuse large B-cell lymphoma.