SERPINE1 and type 2 diabetes mellitus: Decreased clot permeability [3] and impaired efficiency of fibrinolysis [4] in T2DM have been attributed to multiple alterations, including elevated plasminogen activator inhibitor 1 (PAI-1) [5] and thrombin activatable fibrinolysis inhibitor (TAFI) [6], increased glycation of fibrinogen [7] and plasminogen [8], and enhanced thrombin generation (TG) [9] in association with low-grade systemic inflammation [4].