The results showed that overexpression of miR-151a-3p promoted the suppressive effect on TMZ resistance, which was induced by SBF2-AS1 knockdown in GBM cells, while inhibition of miR-151a-3p reversed the SBF2-AS1 knockdown-mediated apoptosis in GBM cells in response to TMZ (Fig. 5e and f). This evidence concerns the gene SBF2 and glioblastoma.