Meanwhile, the lncSBF2-AS1 transfer of TMZ-resistant exosomes downregulated XRCC4 expression in Pri GBM and N3S cells (Additional file 5 Figure S4B), and exosomal lncSBF2-AS1 accelerated the DNA damage repair in GBM recipient cells after TMZ treatment (Additional file 5 Figure S4C and D). Here, XRCC4 is linked to glioblastoma.