Then the exosomes were used to treat parental cells and we found that the apoptosis of parental cells, treated with Rec GBM and N3T3rd exosomes showed a significant decrease after TMZ treatment, however, knockdown of exosomal SBF2-AS1 reversed the apoptosis of GBM cells (Fig. 7f, g and h). Here, SBF2 is linked to glioblastoma.