HAVCR2 and renal cell carcinoma: Therefore, we firstly detected and compared the differential expressions of several immune checkpoints (PD-1, PD-1/2 and TIM-3) between primary and metastatic tumors in Chinese RCC patients, hopefully, to provide a laboratory basis for predicting the efficacy of immunotherapy in patents with mRCC and ultimately offer some insights into the realization of individualized treatment.