Therefore, we firstly detected and compared the differential expressions of several immune checkpoints (PD-1, PD-1/2 and TIM-3) between primary and metastatic tumors in Chinese RCC patients, hopefully, to provide a laboratory basis for predicting the efficacy of immunotherapy in patents with mRCC and ultimately offer some insights into the realization of individualized treatment. This evidence concerns the gene HAVCR2 and metastatic neoplasm.