FOXM1 is required for the Kras-induced formation of lung cancer by activating genes critical for the nuclear factor-kB (NF-kB) and c-Jun N-terminal kinase (JNK) pathways, such as Ikbkb, Nfkb1, Nfkb2, Rela, Jnk1, N-Myc, Pttg1 and Cdkn2a. The gene discussed is MAPK8; the disease is lung cancer.