FOXM1 protein levels are increased in adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, large cell neuroendocrine carcinoma (LCNEC) and small cell neuroendocrine carcinoma (SCLC) compared with those in corresponding normal lung tissues [21, 25, 28, 29]. This evidence concerns the gene FOXM1 and large cell neuroendocrine carcinoma.