At the same time, inhalational allergens (such as HDM) can promote ROS generation, while upregulated ROS induced by fatty acid binding protein 4 (FABP4) consequently activates FOXM1, leading to allergic airway inflammation (IL-4, IL-5, and IL-13) and epithelial barrier dysfunction (structural and functional abnormalities of E-cadherin), which are involved in asthma. Here, IL13 is linked to asthma.