MACROD2 and cancer: Genome-wide DNA copy-number analyses across human cancers have indeed revealed that common focal deletions of MACROD2 genomic locus happen in multiple malignancies, such as in stomach adenocarcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, esophageal carcinoma, uterine corpus endometrial carcinoma, uterine carcinosarcoma, lung adenocarcinoma, liver hepatocellular carcinoma and thyroid carcinoma [36,37].