To investigate the molecular mechanisms governing dependency on RNMT, we investigated whether cells sensitive to RNMT siRNA transfection (MCF7, HCC-1806, JIMT-1 and T47D) exhibited differences in RNMT expression and protein synthesis compared with those which are insensitive (IMEC, BT-549, MDA-MB-231, CAMA-1 and ZR-75-1) (figure 3). This evidence concerns the gene RNMT and hepatocellular carcinoma.