Figure 8A shows that the activity of caspase-1 was enhanced in the lesional skin tissues from AD-like mice, which was repressed by physcion (p < 0.05). Physcion also significantly reduced the protein expression level of caspase-1 in the lesional skin tissues (Figure 8B,C, p < 0.05). The regulatory effects of physcion on caspase-1 activation in the lesional skin tissues were similar to those of DEX-treated group (Figure 8). This evidence concerns the gene CASP1 and Alzheimer disease.