Although all kinesins resulted in a WHO grade-dependent upregulation, only the knockdown of KIF11 with two different siRNAs targeting KIF11 led to an inhibited proliferation of the benign meningioma cell line Ben-Men-1 and the anaplastic NCH93 cell line in vitro, indicating a pivotal role in tumorigenesis and the sustained growth of meningiomas. This evidence concerns the gene KIF11 and meningioma.