ERBB2 and neoplasm: However, we reported previously that inclusion of 1 mol% FA-PEG2000-DSPE into lipid-based cationic nanoparticles composed of OH-Chol and Tween 80 could efficiently deliver siRNAs into KB cells, and FA-PEG-modified nanoplexes of HER-2 siRNA introduced by intratumoral injection significantly inhibited the tumor growth of KB xenografts compared with Cont siRNA, but PEG-modified nanoplexes did not [30], indicating that the in vivo anti-tumor effects by PEG-modified and FA-PEG-modified siRNA nanoplexes were well correlated with the in vitro ones.