AREG and central nervous system cancer: By combining these two techniques, we identified a relevant 26-gene panel (Supplementary Figure S1): Nine genes involved in neurotrophin pathways (AKT3, EGF, AREG, ERBB4, neuregulin 2, neuregulin 3, neuregulin 4, BRAF, internexine-a), six genes encoding neurotrophins and their receptors (NGF, NTSR2, NTRK1, NTRK2-FL, NTRK2-T1, NTRK3), three glycosylation-related genes (CHI3L1, KLRC3, ST3GAL5), two genes implicated in autophagy (PARK2, PINK1), three genes known to occur in hypoxia and angiogenesis (VEGF-A, VEGFR-2, VEGFR-3) and three glioma markers (OLIG2, NANOG, SYP).