Among the 4 groups of gallbladder cancer, there were significant differences in both OS and progression-free survival (PFS), wherein the patients with PD-L1− and CD8high tumor- infiltrating lymphocytes (TILs) had the best survival, and the patients with PD-L1+ and CD8low TILs had the worst survival [38]. The gene discussed is CD274; the disease is gallbladder cancer.