Consistent with these findings, the level of CD44+/CD133+ CSCs was significantly higher in tumor tissues with low CD8+ T cells infiltration/high PD-L1 expression or high CD8+ T cells infiltration/high PD-L1 expression than in those with low CD8+ T cells infiltration/low PD-L1 expression (p = 0.0006; Figure 4C). The gene discussed is CD274; the disease is neoplasm.