This therapeutic approach utilizes the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) or programmed death 1 (PD-1)/programmed death receptor ligand-1 (PD-L1) blocking antibodies to release the brakes from suppressed T cells, allowing them to be activated and recover their antitumor activity [18], suggesting re-activation of antitumor immunity as a promising strategy for cancer treatment. This evidence concerns the gene CD274 and cancer.