CD274 and ovarian cancer: Others drugs able to up-regulate PD-L1 expression in ovarian cancer models are paclitaxel, carboplatin, cisplatin, gemcitabine, and capecitabine [31].Interestingly, Peng J et al. showed, from a collection of cancer cells from ovarian cancer patients with massive ascites, that the expression of PD-L1 increased 5-fold on day four after combined paclitaxel and carboplatin therapy and decreased to pre-treatment levels on day 11, demonstrating the reversibility of PD-L1 expression induced by chemotherapy [31].