A low-dose of cyclophosphamide combined with an anti-PD1 synergistically induced antigen-specific immunity and the infiltration of CD8+ and CD4+FoxP3−T cells as well as it induced the suppression of the CD4+ CD25+ FoxP3+ regulatory T cell function, thus resulting in the increase of tumor-free survival in a model of cervical cancer [26,27]. This evidence concerns the gene CD8A and neoplasm.