Malliard et al. have demonstrated successfully generation of cDC1s with sustained TH1 responses against tumor-associated antigens with the use of a combination of cytokines and adjuvants such as IFN-γ, IFN-α, and polyinosinic:polycytidylic acid (poly(I:C)) during the IL-1β/TNF-α-induced DC maturation process in vitro [96]. This evidence concerns the gene IFNG and neoplasm.