CD4 and neoplasm: The authors also compared whether neurosphere lysate served as a better antigen than GL261 lysate and found that, while the tumor size was largely similar between groups treated with GL261 lysate pulsed DCVs and groups treated with STDENVANT, STDENVANT-treated groups had a higher percentage of IFN-γ producing CD8+ and CD4+ T cells in the tumor-infiltrating lymphocytes.