MC4R and isolated hemihyperplasia: With respect to the question of whether SAS patients’ appetite and food intake is increased, we previously verified the effect of IH, a hallmark of SAS, on the expression(s) of major appetite regulatory neuropeptide and receptor genes such as POMC, CART, GAL, GALP, GHRL, QRFP, AGRP, NPY, and MC4R, revealing the up-regulation of anorexigenic POMC and CART mRNAs by IH [4].