ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: We transfected donor cells to generate targeted EVs able to deliver Imatinib or BCR-ABL siRNA to CML cells in order to overcome pharmacological resistance, showing that modified EVs, containing IL3-Lamp2B and loaded with Imatinib, are able to specifically target tumor cells in vivo, causing a reduction in tumor size [65].