Western blot analysis showed that the ratio of Bax/Bcl-2 was up-regulated and caspase-3 was activated after treatment with peperomin E. In addition, cell-cycle arrest at G2/M phase was also revealed according to the data of flow cytometry, which is different to peperomin E on non-small-cell lung cancer cell lines which cell-cycle arrest at G1/S phase [15]. The gene discussed is CASP3; the disease is non-small cell lung carcinoma.