Relevance of our results to SDB is supported by finding that 12 of the 17 available lead loci SNPs across all analyses had at least a nominal association with the AHI (S5 Table), including the associations for HK1 rs72805692 and IL18R1 region rs78136568 SNPs (p = 8.1 × 10−5 and 7.2 × 10−5 respectively). The gene discussed is IL18R1; the disease is sleep apnea syndrome.