Besides the proband (IV:4), nonfunctioning pituitary tumors were identified in three carriers of the CDKN1B variant, including two microadenomas (III:4 and III:7) and one macroadenoma (IV:1) (Table 1), with functionality classified on the basis of measurements of IGF-1 and prolactin. This evidence concerns the gene CDKN1B and pituitary tumor.