Although we could not find a difference in the activation of NF-κB and ERK between WT and Nlrp12-/- HCC, the involvement of NLRP12 in the downregulation of these pathways in myeloid and T cells during HCC and a contribution of such processes in the suppression of HCC cannot be completely excluded. The gene discussed is NLRP12; the disease is hepatocellular carcinoma.