Consistent with pathological features, there was significantly higher expression of cytokines IL-6 (Il6) and TNFα (Tnfa), chemokines KC (Cxcl1), MIP2 (Cxcl2), and MCP1 (Ccl2), and tumor-promoting molecule COX2 (Cox2) in Nlrp12-/- HCC (Figure 2C and Figure 2—figure supplement 1D). This evidence concerns the gene TNF and neoplasm.