NLRP12 and experimental autoimmune encephalomyelitis: For example, NLRP12-mediated inhibition of NF-κB in myeloid cells contributes to protection against intestinal inflammation and tumorigenesis, in T cells it is implicated in experimental autoimmune encephalomyelitis (Lukens et al., 2015), and in osteocytes it is involved in osteoclast differentiation (Krauss et al., 2015).