NLRP12 and medical procedure: NLRP12 negatively regulates NF-κB and ERK in macrophages, dendritic cells, and T cells (Lukens et al., 2015; Zaki et al., 2014; Zaki et al., 2011), and increased colorectal tumorigenesis in Nlrp12-/- mice is associated with higher activation of the NF-κB and ERK signaling pathways (Allen et al., 2012; Zaki et al., 2011).