There was increased expression of pro-proliferative and tumor promoting genes such as Ccnb1, Ccnd1, Survivin, and Myc (Figure 4A), while the expression of Cdkn1a, an inhibitor of cell cycle progression, was significantly reduced in Nlrp12-/- HCC (Figure 4A). This evidence concerns the gene CCND1 and hepatocellular carcinoma.