Genome sequencing and transcriptomics analyses have identified CTCNB1, WNT, AXIN, TP53, CCND1, CDKN2A, TERT, ARID1A, and ARID2 as major genes whose alterations cause HCC induction (Huang et al., 2012; Marquardt et al., 2015). The gene discussed is TP53; the disease is hepatocellular carcinoma.