ADGRE1 and hepatocellular carcinoma: F4/80 (Emr1) mRNA levels were unchanged between healthy WT and Nlrp12-/- livers (Figure 2—figure supplement 1G), suggesting that increased expression of macrophage chemoattractant proteins MIP2 and MCP1 in Nlrp12-/- HCC tissue resulted in increased infiltration of macrophages/Kupffer cells.