Experimental studies demonstrated that NLRP12 protects mice from colitis, colorectal tumorigenesis, and experimental autoimmune encephalomyelitis (EAE) (Allen et al., 2012; Lukens et al., 2015; Zaki et al., 2014; Zaki et al., 2011). Here, NLRP12 is linked to experimental autoimmune encephalomyelitis.