However, wild type and Keap1 null cancer cells have significant changes in metabolism (Best et al., 2018; DeNicola et al., 2015; DeNicola et al., 2011; Mitsuishi et al., 2012; Romero et al., 2017; Sayin et al., 2017), yet tumors derived from cells of these genotypes do not show significant alterations in levels of nutrients whose metabolism is known to be altered by Keap1 loss. Here, KEAP1 is linked to cancer.