Lastly, we hypothesized that tumor genetics would also alter TIF composition, and studied the effect of Keap1 loss because Keap1 null cancer cells have dramatic alterations in cell-intrinsic metabolism (Best et al., 2018; DeNicola et al., 2015; DeNicola et al., 2011; Mitsuishi et al., 2012; Romero et al., 2017; Sayin et al., 2017). Here, KEAP1 is linked to cancer.