VEGFA and neoplasm: For example, anti-VEGF therapies are thought to normalize tumor vasculature leading to decreased interstitial pressure and increased perfusion (Jain, 2001), and a number of approaches have been developed to limit the stromal compression of tumor blood vessels that increases tumor pressure and decreases tumor perfusion (Olive et al., 2009; Pinter and Jain, 2017; Provenzano et al., 2012).