Another paper measured the ratio of phosphorylated N2BA to phosphorylated N2B cardiac titin isoforms in myocardial samples from patients with AS and T2DM and found a significant increase relative to nonfailing myocardium, while the N2BA:N2B expression ratio remained unaltered, suggesting hypophosphorylation of the N2B isoform and hyperphosphorylation of the N2BA isoform 115. Here, TTN is linked to type 2 diabetes mellitus.