In addition, 17-aminogeldanamycin significantly reduces c-MYC transcript level while not affecting the frequency of cells positive for ATP-binding cassette, sub-family B, member 5 (ABCB5) [32], which is a drug efflux transporter that mediates chemoresistance and marks melanoma-initiating cells [33]. The gene discussed is ABCB5; the disease is melanoma.