Interestingly, the IL-33 receptor (IL1RL1) and IL-33 are among the 100 most highly upregulated genes in a transcriptome study of human islets with T2D (IL1RL1 rank 6 and IL33 rank 26) pointing to a need for activation of restorative pathways in human T2D [13]. Here, IL1RL1 is linked to type 2 diabetes mellitus.