Type-2 Ryanodine receptors (RyR2) release calcium through a calcium-induced mechanism in the sarcoplasmic reticulum, and its mutation has been found in a majority of cases of catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1), with more than 150 associated mutations demonstrated [27]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia 1.