Currently, various molecules have been identified as closely correlated with ESCC, such as transgelin (TAGLN) and proteasome activator 28-beta subunit (PA28β) [15], pituitary tumor transforming gene (PTTG) [6], transglutaminase 3 (TGM) by proteomics [2]. This evidence concerns the gene PSME2 and esophageal squamous cell carcinoma.