After microarray studies and IPA, cellular canonical pathways with most differentially changed gene expression included: Interferon Signalling, Protein Ubiquitination Pathway, Activation of IRF by Cytosolic Pattern Recognition Receptors, Glioma Invasiveness Signalling, Oncostatin M Signalling, Coagulation System, IL-17A Signalling in Fibroblasts, Prostanoid Biosynthesis, Glucocorticoid Receptor Signalling, Parkinson’s Signalling, and 64 other pathways in which FOS was involved, see Table 1, Fig. 1, Supplementary Table S4. This evidence concerns the gene OSM and central nervous system cancer.