PPM1H suppresses the activation of SMAD signalling and participates in the process of mesenchymal differentiation.25 In particular, knockdown of PPM1H in pancreatic cancer cells results in increased VIM expression and changes in other EMT markers,24–26 suggesting an obvious role of PPM1H in the mesenchymal phenotype. The gene discussed is PPM1H; the disease is familial pancreatic carcinoma.