PPM1H knockdown induced the reduction of the tumour suppressor p27 at the protein level,26 and low p27 protein expression was associated with chemo-resistance, such as cisplatin and carboplatin resistance.27 Thus, we proposed that the benefits of chemotherapy for patients with low PPM1H expression might be offset by the reduction of p27 in stage III CRC. Here, PPM1H is linked to colorectal carcinoma.