Other noteworthy gene-based associations included those with: IMP3, which contributes to self-renewal and tumor initiation, properties associated with cancer stem cells41; PPP2R1B, which encodes the beta isoform of subunit A of Protein Phosphatase 2A, itself a tumor suppressor involved in modulating estrogen and androgen signaling in breast cancer42; and SEMA4A43, recently shown to regulate the migration of cancer cells as well as dendritic cells44. The gene discussed is IMP3; the disease is cancer.