For example, the EUGENE gene-based P-value for GSTM2 was 6.6 × 10−8, while the best individual eQTL showed more moderate association with breast cancer risk (GCTA-COJO conditional association P = 4.1 × 10−5; five of the 14 sentinel eQTL tested for this gene were nominally associated with disease risk (Supplementary Data 11). Here, GSTM2 is linked to breast cancer.