We observed a significant overlap between genes that underwent PCPA in this data set and those that were similarly affected by THZ531 treatment, even though they represent two different cancer cell types and were studied at different time points after perturbation of different targets – U1 at 4 and 8 h37 and CDK12 at 2 h (this study) (Supplementary Fig. 7a; Supplementary Data 4). Here, CDK12 is linked to cancer.