In addition, using an in vitro OGD/reperfusion model, Su et al.29 has reported that microglial TRAF2 knockdown inhibited microglia-mediated secretion of NFκB and IL17 and reduced I/R-induced neuronal apoptosis, suggesting a harmful role of TRAF2 in cerebral ischemia. Here, NFKB1 is linked to brain ischemia.