Signaling through AKT, ERK, and STAT3 pathways controls cell proliferation and these molecules are constitutively phosphorylated in ABC-DLBCL (OCI-Ly3 and Su-2) but not in GCB-DLBCL (Su-4 and OCI-Ly7) cell lines (Suppl Fig. 1A). The gene discussed is STAT3; the disease is diffuse large B-cell lymphoma.