However, treatment with 2 mM of EP significantly decreased cell viability and cell number in both GBC and ABC type cell lines (Fig. 1d–g and Suppl Fig. 1B–E), indicating that HMGB1-mediated cell survival signaling was constitutively activated in the ABC type DLBCL cells. The gene discussed is HMGB1; the disease is diffuse large B-cell lymphoma.