We explored whether SLC5A2 SNPs were associated with (i) fasting glucose, the post-challenge glucose increase in oral glucose tolerance tests and HbA1c; (ii) the prevalence of T2DM, and (iii) baseline coronary artery disease (CAD) as well as incidence of cardiovascular events during follow-up. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.