TIMP2 and colorectal carcinoma: It is therefore possible that TIMP2-418G/C SNP induced down-regulation may alter TIMP MMP and non-MMP functions and disturb the physiological equilibrium between MMPs and TIMPs resulting in altered TIMP function including decreased inhibition and increased MMP activity which leads to altered ECM homeostasis and other physiological alterations which are critical events in neoplastic progression including that of CRC as discussed earlier [5,9,10,12].