TIMP2 and neoplasm: TIMP2 is a highly potent MMP inhibitor capable of inhibiting all MMPs particularly gelatinases, MMP2 and MMP9, is constitutively expressed in contrast with other TIMPs and MMPs which are inducible except MMP2 and is an important mediator in the activation of ubiquitously expressed pro-MMP2 and increased expression of MMP2 has been associated with tumor growth and invasion [13].