SIRT6 and Hyperglycemia: Our results suggested that SIRT6 positively correlated with TET2 in humans and rats, and there existed a link between glucose and SIRT6 and TET2. A possible model in T2DM patients might work as Fig. 4b, in which hyperglycemia could promote DNA demethylation via upregulation of SIRT6 and TET2.