In T2DM patients and controls, the Pearson correlation analysis revealed that glucose was positively associated with TET2 (r = 0.174, p = 0.036) and SIRT6 (r = 0.162, p = 0.045), while SIRT6 was positively associated with TET1 (r = 0.151, p = 0.039) and TET2 (r = 0.277, p < 0.001). This evidence concerns the gene SIRT6 and type 2 diabetes mellitus.