SIRT6 and type 2 diabetes mellitus: Student’s t test showed that the mRNA expression levels of TET2, TET3, and SIRT6 were 1.47-, 1.17-, and 1.43-fold higher in T2DM patients than that in the controls (p = 0.012, p = 0.026, and p = 0.035, respectively) (Fig. 3a).