Neurodegeneration has been checked using NeuN labeling in different mouse PD models, including 6-OHDA injections [46], adeno-associated-virus vector (AAV9) for α-synuclein [57] and transgenic mouse overexpressing human α-synuclein under the Thy-1 promoter (Thy-α-syn) [11]. This evidence concerns the gene THY1 and Parkinson disease.