To explore the oncogenic role of C12orf59 in GC, we suppressed C12orf59 expression in MKN-45 and AGS cell lines that have high levels of C12orf59, and overexpressed C12orf59 expression in HGC-27 cell lines that have low level of C12orf59 (Fig. 2a). Here, TMEM52B is linked to gastric cancer.