TMEM52B and gastric cancer: In addition, high expression of C12orf59 was positively associated with N status (P = 0.007; P = 0.012, respectively) and overall clinical stage (P = 0.006; P = 0.011, respectively) both in training and validation cohorts of GC cases (Table 1), implying a potential role of C12orf59 in promoting GC metastasis.