Cell-based assays on the K-Ras-mutated NSCLC cell lines A549 and H2122 with overexpressed miR-199b (Additional file 1: Figure S2c) showed significant suppression of cell proliferation (Fig. 3a), soft agar colony formation (Fig. 3b) and invasion (Fig. 3c) in both cell lines. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.