HLA-C and neoplasm: Neoantigen prediction involves a series of computational steps, starting with the identification of mutations at the DNA level by comparing the whole exome sequences with those matched normal cells, followed by identifying targeted neoepitopes with the help of tumor RNA expression profiling, and finally determining the binding affinity of predicted epitopes to the MHC molecules with the use of software programs such as NetMHC or SYFPEITHI [98, 102].