Furthermore, the secretion of immunosuppressive cytokines by the hypoxic TME can induce apoptosis of CD8+ T cells and the production of Tregs, along with inhibition of the activation of APCs; this, in turn, results in the failure of DCs to present tumor antigens to T cells for the activation of an antitumor response [161]. The gene discussed is CD8A; the disease is neoplasm.