Mesothelin might not be essential for the growth and reproduction of both wild type and mesothelin knockdown mice [121], although its aberrant or overexpression in preclinical and clinical studies showed that it plays an active role in both tumor malignancy and aggressiveness by promoting tumor proliferation, leading to invasion, metastasis, and conferring resistance towards cytotoxic agents [119]. This evidence concerns the gene MSLN and neoplasm.