FAP and familial pancreatic carcinoma: As expected, higher levels of FAP expression in patients were associated with shorter overall survival compared with patients showing lower FAP expression, suggesting that FAP is important for tumor progression and metastasis in pancreatic cancer [31].Deletion of FAP gene and pharmacologic inhibition of FAP enzymatic activity reduced the tumor burden probably through disturbing stromagenesis, angiogenesis, and promotes nti-tumor immune responses.