Notably, some of these unreported variants, including SNVs in Vanin2 (VNN2), Calcium Voltage-Gated Channel Subunit Alpha1 D (CACNA1D), Melanin Concentrating Hormone Receptor 2 (MCHR2), Unc-5 Netrin Receptor D (UNC5D), or Mastermind Like Transcriptional Coactivator 2 (MAML2), showed high values in the 0 to 5 scale assigned by DREAMgenics (DG) value (integrated score of several predictive algorithms [34], see supplemental methods for details) used to predict deleterious mutations and, therefore, they might constitute new driver events in chondrosarcoma (Figure 3E and Figure 4B). This evidence concerns the gene UNC5D and chondrosarcoma.