Notably, some of these unreported variants, including SNVs in Vanin2 (VNN2), Calcium Voltage-Gated Channel Subunit Alpha1 D (CACNA1D), Melanin Concentrating Hormone Receptor 2 (MCHR2), Unc-5 Netrin Receptor D (UNC5D), or Mastermind Like Transcriptional Coactivator 2 (MAML2), showed high values in the 0 to 5 scale assigned by DREAMgenics (DG) value (integrated score of several predictive algorithms [34], see supplemental methods for details) used to predict deleterious mutations and, therefore, they might constitute new driver events in chondrosarcoma (Figure 3E and Figure 4B). The gene discussed is MAML2; the disease is chondrosarcoma.