This clone includes previously known mutations, such as that previously found by Sanger sequencing in IDH2 (R172G) [2,4] or mutations in COL2A1 (G939Wfs*5 and P668Lfs*120) [5,6], as well as other unreported non-synonymous mutations presenting high scores in impact prediction algorithms, such as VNN2, CACNA1D, MCHR2, UNC5D, or MAML2, which possibly contribute to chondrosarcoma progression must be studied in detail. This evidence concerns the gene COL2A1 and chondrosarcoma.