They studied the effects of berberine in colon cancer cell lines and findings revealed that berberine inhibited glucose uptake and reduced the transcription of genes, such as GLUT1 (glucose transporter 1), LDHA (lactate dehydrogenase A) and HK2 (hexokinase 2), involved in glucose metabolism of colon cancer cells. The gene discussed is SLC2A1; the disease is colonic neoplasm.