Kinases of the Janus kinase (JAK) family and transcriptional factors of the STAT (signal transducer and activator of transcription) family form a highly dynamic and orchestrated membrane-to-nucleus signaling module that has been extensively investigated, and an overwhelmingly increasing list of scientific reports have provided evidence of natural products mediated targeting of the JAK-STAT pathway in different cancers. This evidence concerns the gene SOAT1 and cancer.