Translocation renal cell carcinoma (tRCC) is characterized by gene fusions involving two members of the Microphthalmia-associated transcription factor (MiTF) family: TFE3 and TFEB located on Xp11.2 and 6p21.1 respectively [4,11]. Here, TFE3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.