In this study, we treated mouse models of lung squamous cell carcinoma with three different CPAs (MEK inhibitor: AZD6244, PI-3K inhibitor: XL-147 and glucocorticoid: Budesonide) and screened the expression level changes of exosomal miRNAs responding to CPAs treatment. This evidence concerns the gene MAP2K7 and squamous cell lung carcinoma.