VEGFA and neoplasm: For instance, angiogenic factors (e.g., VEGF) and growth factors (e.g., IL-8) facilitate angiogenesis and cancer cell proliferation [13,14,15,16]; matrix metalloproteinases (e.g., MMP-9) and proteases (tryptase and chymase) degrade extracellular matrix (ECM) components and thereby favor the implantation of tumor cells [17,18].